Multisystem Inflammatory Syndrome in Children (MIS-C) has emerged as one of the most complex and unpredictable pediatric conditions linked to post-infectious immune activation. Characterised by fever, inflammation, and multi-organ involvement, MIS-C requires rapid recognition, multidisciplinary assessment, and coordinated care pathways across emergency, cardiology, infectious disease, rheumatology, and critical care teams. This session explores the evolving understanding of MIS-C, its clinical presentations, diagnostic challenges, and long-term implications for growing children.

With new variants, evolving epidemiology, and increasing need for follow-up services, clinicians actively look for an Pediatrics Conference to access current evidence, management protocols, and case-based learning. In this session, participants will examine how MIS-C overlaps with Kawasaki disease, toxic shock, and severe acute infections, and how to differentiate these conditions using a combination of laboratory markers, imaging findings, and clinical progression. The session also reviews inflammatory pathways, the role of viral triggers, and how immune dysregulation leads to cardiac, gastrointestinal, neurologic, and hematologic manifestations.

A major theme is designing sustainable pediatric inflammatory disease care pathways that ensure continuity long after the initial episode. Many children require ongoing cardiology follow-up, echocardiography for coronary involvement, and monitoring for fatigue, cognitive effects, or emotional distress. Case examples highlight how MIS-C affects not only medical trajectories but also school attendance, physical activity, and caregiver wellbeing. The session emphasises the importance of clear communication with families during the uncertain early phase and throughout recovery, addressing fear, misinformation, and concerns about recurrence.

Participants will also explore global disparities in MIS-C recognition and treatment, especially in regions with limited access to laboratory panels, IVIG, biologics, or pediatric ICUs. The session outlines practical, adaptable approaches for low- and middle-resource settings, including simplified diagnostic algorithms, early triage systems, and networked referral pathways. Ethical considerations, documentation strategies, vaccination guidance post-MIS-C, and long-term data from follow-up registries will also be discussed. By the end, attendees will be equipped with the skills, judgement, and communication tools needed to deliver coordinated, evidence-based MIS-C care.