Advances in screening, diagnosis, and targeted therapies have transformed outcomes for many children with Cystic Fibrosis in Children, yet day-to-day life still involves complex treatment routines, frequent monitoring, and careful coordination between families and multidisciplinary teams. This session explores how pediatric services can deliver high-quality, family-centred care across the care continuum—from newborn screening and diagnostic confirmation to disease-modifying therapies, nutritional support, and preparation for transition to adult services. Participants will examine how to integrate pulmonary, gastrointestinal, endocrine, and psychosocial care in a way that is manageable for families and sustainable for teams.

Clinicians and allied professionals increasingly seek Pediatrics Conference that provide practical guidance on applying guidelines in real-world settings. In this session, attendees will explore contemporary approaches to airway clearance techniques, inhaled therapies, infection prevention and control, and the use of CFTR modulators. Discussions will highlight how to interpret lung function trends, manage pulmonary exacerbations, and optimise growth and nutrition in childhood and adolescence. The importance of early, proactive management of complications such as CF-related diabetes, liver disease, bone health issues, and sinus disease is woven throughout.

A central theme is the design of resilient pediatric cystic fibrosis care pathways that support adherence, minimise treatment burden, and respond flexibly to the changing needs of families over time. Case examples will illustrate how to address challenges such as treatment fatigue, school disruption, mental health difficulties, and the impact of chronic infection on family life. Participants will consider how to organise multidisciplinary clinics, use telehealth for remote monitoring, and coordinate with local services to reduce travel while maintaining high standards of care. Strategies for supporting siblings, caregivers, and school teams are also discussed.

The session will additionally explore issues of equity, ethics, and global variation, including access to newborn screening, specialist centres, advanced therapies, and transplant pathways. Attendees will reflect on how to communicate about prognosis in the era of transformative treatments, how to navigate decisions around clinical trials, and how to support adolescents and young adults in planning education, careers, and family life. By the end, participants will have updated knowledge and practical tools to enhance the everyday care experience for children living with cystic fibrosis and the people who support them.