Epidermolysis Bullosa Acquisita (EBA) is considered one of the rarest subepidermal bullous diseases in Western Europe, with an estimated annual incidence ranging from 0.2 to 0.5 cases per million people. The condition arises due to autoantibodies targeting collagen type VII, an important component of the anchoring fibrils within the dermal-epidermal junction. Modern wound care today is also called moist wound healing. Moist Wound Healing is a method of wound healing by maintaining isolation of the wound environment by remaining moist, using dressings that can maintain wound moisture. The purpose of applying wound care to newborns with Epidermolysis Bullosa Acquisita is to accelerate the wound healing process and increase comfort in infants. The method used by applying modern wound care with data collection techniques using nursing methodology and the subject in this case report is a newborn baby. One of the nursing problems that arise in clients with Epidermolysis Bullosa Acqusita in the NICU of Budi Kemuliaan Hospital is impaired skin integrity. The results obtained in the application of interventions after 3 days the wound became moist, the color of the wound was red, the size of the wound did not increase, the exudate decreased, around the wound there was no edema and no redness, the baby's C-Reactive Protein laboratory results decreased, the baby's body temperature ranged from 36.5?c - 37?c and most importantly the baby looked comfortable and not restless. Thus, it can be concluded that the importance of nursing care for newborns with EBA is carried out with modern wound care which is proven to be effective in accelerating wound healing and preventing infection. In addition, it is important to involve parents in this modern wound care, so that when the baby goes home, the parents are able to carry out wound care independently. Lastly let's make neonates comfort.
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