Pediatric Clinical Genomics Implementation focuses on the integration of genetic testing, sequencing technologies and molecular diagnostics into routine pediatric care. As genomics becomes central to modern medicine, pediatricians are increasingly expected to interpret genomic data, apply it to diagnostic pathways and incorporate findings into long-term care planning. For children, genomic insights can clarify complex presentations, identify rare disorders earlier, guide targeted therapies and inform risk assessment for family members. This session examines how genomics can be effectively translated from research settings into everyday pediatric practice in a responsible, ethical and clinically meaningful way.

Implementation requires more than simply ordering genetic tests. It involves developing workflows that determine when testing is appropriate, how results should be interpreted, how families should be counselled and how information should be documented. Many clinicians explore evolving trends at a pediatrics conference, where they learn about new sequencing platforms, variant-interpretation frameworks and best practices for integrating genomic knowledge with clinical decision making. Genomic medicine is rapidly expanding, and ensuring that pediatric teams can navigate this landscape is essential for accurate diagnosis and personalised care.

Children present unique challenges in genomics. Their genetic conditions may be rare, their phenotypes may evolve with age, and their ability to express symptoms is limited. Therefore, genomic testing often requires coordinated involvement of geneticists, pediatricians, laboratory specialists, counsellors and families. The process includes explaining testing options, obtaining informed consent, interpreting variants of uncertain significance and discussing implications for siblings or future pregnancies. The ethical dimensions are significant, especially when findings may affect long-term autonomy or reveal incidental information. Effective Pediatric Clinical Genomics Implementation must balance clinical benefit with sensitivity to these considerations.

Practical application includes newborn screening expansions, diagnostic exome sequencing, pharmacogenomic testing, cancer-predisposition assessments and gene-specific therapies. Genomic data can also inform surveillance plans, dietary interventions, medication choices and early interventions for developmental or metabolic disorders. A strong understanding of pediatric genomics workflows helps ensure that sequencing results translate to meaningful improvements rather than isolated laboratory reports.

As genomic technology becomes cheaper and more accessible, its integration into pediatric practice will continue to grow. Implementing genomics effectively requires robust education, infrastructure, decision-support tools and clear communication among families and providers. This session emphasises how clinical teams can use genomics to provide earlier diagnoses, tailor treatments and deliver more precise pediatric care while managing the ethical, technical and organisational challenges that come with it.